In combination w/ 5-FU & folinic acid for adjuvant treatment of stage III (Duke's C) colon cancer after complete resection of primary tumor; treatment of metastatic CRC.
Dosage/Direction for Use
To be administered as 2-6 hr IV infusion before fluoropyrimidines. AdultAdjuvant treatment 85 mg/m2 every 2 wk for 12 cycles (6 mth). Metastatic CRC 85 mg/m2 every 2 wk.
Contraindications
Pregnancy & lactation. Peripheral sensitive neuropathy, myelosuppression, severe renal impairment.
Special Precautions
Monitor renal function in case of moderate renal impairment. History of allergic reaction to platinum compd. Avoid extravasation. Monitor neurological & haematological toxicity before therapy & then periodically. In case of acute laryngopharyngeal dysaesthesia, administer the next infusion over 6 hr. Discontinue in case of unexplained resp symptoms. Male patients should not father a child during & until 6 mth after the end of therapy. May impair ability to drive or operate machinery.
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